Telpride 40mg (Telmisartan)

Brand Name               : Telpride 40mg

Packing                      :  10*10

Pharmacology:

1.     Pharmacodynamics:Antagonizes the effect of angiotensin II(vasoconstriction and aldosterone secretion) by blocking the angiotensin II (AT1 receptor) in vascular smooth muscle and the adrenal gland, producingdecreased BP.

2.     Pharmacokinetics:

a.) Absorption:T max is 0.5 to 1 h. Food slightly reducesbioavailability of telmisartan, with an AUC reduction of approximately 6% witha 40 mg dose and 20% with a 160 mg dose. At 40 and 160 mg, the bioavailabilitywas 42% and 58%, respectively. Trough plasma concentrations with daily dosingare approximately 10% to 25% of C max.

b.) Distribution: -Telmisartan is more than 99.5% protein bound. Vd is approximately 500 L.

c.) Metabolism: -Telmisartan is metabolized by conjugation to form a pharmacologically inactiveacyl glucuronide. The glucuronide of the parent compound is the only metabolitethat has been identified in human plasma and urine.

d.) Elimination: -Telmisartan half-life is approximately 24 h and total plasma Cl is more than800 mL/min. After IV or oral administration, more than 97% is eliminatedunchanged in feces via biliary excretion.

Indications:

Treatment of hypertension; for the reductionof the risk of MI, stroke, or death from CV causes in patients 55 y and olderwho are at high risk of developing major CV events and are unable to take ACEinhibitors.