Product Description
Brand Name : Telpride 40mg
Packing : 10*10
Pharmacology:
1. Pharmacodynamics:Antagonizes the effect of angiotensin II(vasoconstriction and aldosterone secretion) by blocking the angiotensin II (AT1 receptor) in vascular smooth muscle and the adrenal gland, producingdecreased BP.
2. Pharmacokinetics:
a.) Absorption:T max is 0.5 to 1 h. Food slightly reducesbioavailability of telmisartan, with an AUC reduction of approximately 6% witha 40 mg dose and 20% with a 160 mg dose. At 40 and 160 mg, the bioavailabilitywas 42% and 58%, respectively. Trough plasma concentrations with daily dosingare approximately 10% to 25% of C max.
b.) Distribution: -Telmisartan is more than 99.5% protein bound. Vd is approximately 500 L.
c.) Metabolism: -Telmisartan is metabolized by conjugation to form a pharmacologically inactiveacyl glucuronide. The glucuronide of the parent compound is the only metabolitethat has been identified in human plasma and urine.
d.) Elimination: -Telmisartan half-life is approximately 24 h and total plasma Cl is more than800 mL/min. After IV or oral administration, more than 97% is eliminatedunchanged in feces via biliary excretion.
Indications:
Treatment of hypertension; for the reductionof the risk of MI, stroke, or death from CV causes in patients 55 y and olderwho are at high risk of developing major CV events and are unable to take ACEinhibitors.
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