Product Description
Product Composition :Telmisartan 80 mg
Brand Name :Telpride 80mg
Composition :Eachtablet Contain Telmisartan 80mg
Packing :10*10
Pharmacology:
1. Pharmacodynamics: Antagonizes the effect ofangiotensin II (vasoconstriction and aldosterone secretion) by blocking the
angiotensinII (AT 1 receptor) in vascular smooth muscle and the adrenal gland, producingdecreased BP.
2. Pharmacokinetics:
a.) Absorption: T max is 0.5 to 1 h. Foodslightly reduces bioavailability of telmisartan, with an AUC reduction ofapproximately 6% with a 40 mg dose and 20% with a 160 mg dose. At 40 and 160mg, the bioavailability was 42% and 58%, respectively. Trough plasma concentrationswith daily dosing are approximately 10% to 25% of C max.
b.) Distribution: -Telmisartan is more than99.5% protein bound. Vd is approximately 500 L.
c.) Metabolism: -Telmisartan is metabolized byconjugation to form a pharmacologically inactive acyl glucuronide. Theglucuronide of the parent compound is the only metabolite that has beenidentified in human plasma and urine.
d.) Elimination: -Telmisartan half-life isapproximately 24 h and total plasma Cl is more than 800 mL/min. After IV or oraladministration, more than 97% is eliminated unchanged in feces via biliaryexcretion.
Indications:
Treatment of hypertension; for the reduction of the risk ofMI, stroke, or death from CV causes in patients 55 y and older who are at highrisk of developing major CV events and are unable to take ACE inhibitors.
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