Product Description
Brand Name :Telpride AM
Composition :Eachtablet Contain Telmisartan 40mg + Amlodepin 5mg
Packing :10*10
Pharmacology
1. Pharmacodynamics:
a.) Telmisartan
It is a competitive antagonist of angiotensin-2 atAT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensiveindividuals. It blocks all overt actions of angiotensin-2 such as: 1.Vasoconstriction, 2. Central & Peripheral sympathetic stimulus, 3. Releaseof aldosterone and adrenaline, 4. Salt and water reabsorption, 5. Centralactions like thirst, vasopressin release, and growth promoting actions on heartand blood vessels.
b.) Amlodipine
Amlodipine is a second generation dihydropyridineCa channel blocker. It exerts it`s antihypertensive, antianginal actionsthrough blocking the influx of Ca ions through voltage gated L-type Ca channelsto the peripheral vascular smooth muscle cells, Coronary smooth muscle cellsand to the myocardial cells. Thus causes dilatation of vascular endothelium,decrease peripheral resistance, & reduce myocardial oxygen demand .Itmarkedly relax arterioles and milder effects on veins. They do not compromisehaemodynamics and cerebral and renal perfusion.
2. Pharmacokinetics:-
a.) Telmisartan
Absorption: Absorbedorally, bioavailability is about 42%
Distribution: Itis distributed in to the body in a highly protein bound form.
Metabolism: Metabolizedby glucuronide conjugation in to an inactive metabolite.
Excretion: Excretedmainly through faeces and rest is excreted through urine.
b.) Amlodipine
Absorption: Wellabsorbed orally.
Distribution: Widelydistributed in a protein bound form.
Metabolism: Metabolizedin liver, but there is no active metabolite
INDICATIONS
ACE inhibitors: Thiazide diuretics:Potentiates effect of these drugs.
Beta Blockers : Best avoided, especially by those withimpaired LV function due to depressant effect on myocardial contractibility
or AV conduction.
Fentanyl: Severe hypotension orincreased fluid volume requirements.
Dual Mechanism for Effective Blood Pressure ControlTelpride AM utilizes the unique combination of Telmisartan and Amlodepin to offer comprehensive management of hypertension. Telmisartan works by relaxing blood vessels, while Amlodepin aids in preventing calcium from entering the heart and blood vessel walls. This dual approach helps reduce cardiovascular risk and supports long-term health outcomes.
Easy Oral Administration and Convenient PackingPresented as film-coated tablets, Telpride AM is taken orally, making administration hassle-free for patients. Each pack contains 100 tablets (10 strips of 10), streamlining routine dosing and storage needs. This well-structured packaging not only preserves tablet integrity but also enhances medication adherence.
FAQs of Telpride AM (Telmisartan + Amlodepin):
Q: How does Telpride AM work to lower blood pressure?
A: Telpride AM synergistically combines Telmisartan and Amlodepin, which act on different pathways to relax blood vessels and reduce resistance, ultimately helping lower elevated blood pressure.
Q: What is the recommended dosage for Telpride AM?
A: The dosage of Telpride AM should be determined by a physician based on each patients response and medical condition. Never adjust your dose without consulting your healthcare provider.
Q: When should Telpride AM be taken during the day?
A: Telpride AM is usually taken once daily at the same time each day. However, your doctor may adjust the schedule to suit your condition and other medications you may be taking.
Q: Where can I purchase Telpride AM in India?
A: Telpride AM is distributed, manufactured, and supplied across India. It is available through licensed pharmacies and medical distributors, but a valid prescription from a healthcare professional is required.
Q: What are the main benefits of using Telpride AM?
A: Telpride AM provides reliable blood pressure control and helps reduce the risk of stroke, heart attack, and other cardiovascular complications in people with hypertension.
Q: How should Telpride AM be stored at home?
A: Store Telpride AM tablets in a cool and dry place, away from direct sunlight and moisture, to maintain their efficacy and prevent degradation.
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