Telpride AM (Telmisartan + Amlodepin)

Telpride AM (Telmisartan + Amlodepin)

Product Details:


Telpride AM (Telmisartan + Amlodepin) Price And Quantity

  • INR/Box
  • 10 Box

Telpride AM (Telmisartan + Amlodepin) Trade Information

  • 1000 Box Per Month
  • 1-3 Days
  • All India

Product Description

Brand Name                 :Telpride AM

Composition                 :Eachtablet Contain Telmisartan 40mg + Amlodepin 5mg

Packing                        :10*10



          1. Pharmacodynamics: 

a.)    Telmisartan

It is a competitive antagonist of angiotensin-2 atAT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensiveindividuals. It blocks all overt actions of angiotensin-2 such as:  1.Vasoconstriction, 2. Central & Peripheral sympathetic stimulus, 3. Releaseof aldosterone and adrenaline, 4. Salt and water reabsorption, 5. Centralactions like thirst, vasopressin release, and growth promoting actions on heartand blood vessels.

b.)  Amlodipine

Amlodipine is a second generation dihydropyridineCa channel blocker. It exerts it`s antihypertensive, antianginal actionsthrough blocking the influx of Ca ions through voltage gated L-type Ca channelsto the peripheral vascular smooth muscle cells, Coronary smooth muscle cellsand to the myocardial cells. Thus causes dilatation of vascular endothelium,decrease peripheral resistance, & reduce myocardial oxygen demand .Itmarkedly relax arterioles and milder effects on veins. They do not compromisehaemodynamics and cerebral and renal perfusion.

2. Pharmacokinetics:-

a.)   Telmisartan

Absorption: Absorbedorally, bioavailability is about 42%

Distribution: Itis distributed in to the body in a highly protein bound form.

Metabolism: Metabolizedby glucuronide conjugation in to an inactive metabolite.

Excretion: Excretedmainly through faeces and rest is excreted through urine.

b.)   Amlodipine

Absorption: Wellabsorbed orally.

Distribution: Widelydistributed in a protein bound form.

Metabolism: Metabolizedin liver, but there is no active metabolite



          ACE inhibitors: Thiazide diuretics:Potentiates effect of these drugs.

        Beta Blockers  : Best avoided, especially by those withimpaired LV function due to depressant effect on myocardial contractibility

                                     or AV conduction.

Fentanyl: Severe hypotension orincreased fluid volume requirements.

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